Size:100ug
Purification:Protein A+G purification
Form:liquid
Purity:?95% as determined by SDS-PAGE
Host:Mouse
Clonality:monoclonal
Clone ID:8D5
Isotype:IgG1
Storage:PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20? for 12 months(Avoid repeated freeze / thaw cycles.)
Background:Focal adhesions are actin-rich structures that enable cells to adhere to the extracellular matrix and at which protein complexes involved in signal transduction assemble. Zyxin(ZYX) is a zinc-binding phosphoprotein that concentrates at focal adhesions and along the actin cytoskeleton. Zyxin has an N-terminal proline-rich domain and three LIM domains in its C-terminal half. The proline-rich domain may interact with SH3 domains of proteins involved in signal transduction pathways while the LIM domains are likely involved in protein-protein binding. Zyxin may function as a messenger in the signal transduction pathway that mediates adhesion-stimulated changes in gene expression and may modulate the cytoskeletal organization of actin bundles.
Immunogen:zyxin
Synonyms:ESP 2, HED 2, ZYX, zyxin, Zyxin 2
Observed MW:80 kDa
Uniprot ID:Q15942
Reactivity:Human, Mouse
Tested Application:ELISA, WB, IHC, IF
Recommended dilution:WB: 1:500-1:5000; IHC: 1:20-1:200; IF: 1:20-1:200
Gene ID:7791
Research Area:Cell Division and Proliferation, Signal Transduction