ZBTB7B Monoclonal Antibody

SKU: BT-MCA3140

Size:100μL

Background:ZBTB7B is a transcription regulator that acts as a key regulator of lineage commitment of immature T-cell precursors. It is necessary and sufficient for commitment of CD4 lineage, while its absence causes CD8 commitment. Development of immature T-cell precursors (thymocytes) to either the CD4 helper or CD8 killer T-cell lineages correlates precisely with their T-cell receptor specificity for major histocompatibility complex class II or class I molecules, respectively. ZBTB7B is a transcriptional repressor of the collagen COL1A1 and COL1A2 genes. It may also function as a repressor of fibronectin and possibly other extracellular matrix genes.

Research_area:Epigenetics and nuclear signaling, Immunology

Target_protein:ZBTB7B

applications:WB, IHC, ICC

Reactivity:Human

Clonality:Monoclonal

Clone ID:7C12

Host:Mouse

Isotype:Mouse IgG1

Gene Symbol/ Name:ZBTB7B

Immunogen:Purified recombinant fragment of human ZBTB7B expressed in E. Coli.

Storage:4°C|-20°C for long term storage

Purification:

Formulation:Ascitic fluid containing 0.03% sodium azide.

Concentration:

Molecular weight(Da):58kDa

UniProt accession:O15156

Synonyms:THPOK, ZFP67, ZBTB15, c-Krox, hcKrox, ZNF857B, DKFZp686G01254, ZBTB7B

GeneID:51043