XPO7 antibody , Cat. # FNab09551

SKU: FNab09551

Size:100ug

Purification:Immunogen affinity purified

Form:liquid

Purity:?95% as determined by SDS-PAGE

Host:Rabbit

Clonality:polyclonal

Clone ID:

Isotype:IgG

Storage:PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20? for 12 months(Avoid repeated freeze / thaw cycles.)

Background:Mediates the nuclear export of proteins(cargos) with broad substrate specificity. In the nucleus binds cooperatively to its cargo and to the GTPase Ran in its active GTP-bound form. Docking of this trimeric complex to the nuclear pore complex(NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP(induced by RANBP1 and RANGAP1, respectively) cause release of the cargo from the export receptor. XPO7 then return to the nuclear compartment and mediate another round of transport. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP-and GDP-bound forms of Ran between the cytoplasm and nucleus.

Immunogen:exportin 7

Synonyms:Exp7, exportin 7, KIAA0745, Ran binding protein 16, RANBP16, XPO7

Observed MW:100 kDa

Uniprot ID:Q9UIA9

Reactivity:Human, Mouse, Rat

Tested Application:ELISA, WB

Recommended dilution:WB: 1:500-1:5000

Gene ID:23039

Research Area:Signal Transduction