WT1 Monoclonal Antibody

SKU: BT-MCA3331

Size:100μL

Background:This gene encodes a transcription factor that contains four zinc-finger motifs at the C-terminus and a proline/glutamine-rich DNA-binding domain at the N-terminus. It has an essential role in the normal development of the urogenital system, and it is mutated in a small subset of patients with Wilm's tumors. This gene exhibits complex tissue-specific and polymorphic imprinting pattern, with biallelic, and monoallelic expression from the maternal and paternal alleles in different tissues. Multiple transcript variants have been described. In several variants, there is evidence for the use of a non-AUG (CUG) translation initiation site upstream of and in-frame with the first AUG. Authors of PMID:7926762 also provide evidence that WT1 mRNA undergoes RNA editing in human and rat, and that this process is tissue-restricted and developmentally regulated.

Research_area:Epigenetics and nuclear signaling, Developmental biology, Cancer, Tags & cell markers

Target_protein:WT1

applications:FCM

Reactivity:Human

Clonality:Monoclonal

Clone ID:5G11A5

Host:Mouse

Isotype:Mouse IgG1

Gene Symbol/ Name:WT1

Immunogen:Purified recombinant fragment of human WT1 (AA: 314-479) expressed in E. Coli.

Storage:4°C|-20°C for long term storage

Purification:

Formulation:Purified antibody in PBS with 0.05% sodium azide.

Concentration:

Molecular weight(Da):49.2kDa

UniProt accession:P19544

Synonyms:GUD, AWT1, WAGR, WT33, NPHS4, WIT-2, EWS-WT1

GeneID:7490