UXT Antibody - Cat. #: CSB-PA880062ESR2HU

SKU: CSB-PA880062ESR2HU

Size :50ul

Clone Number:

Aliases:Androgen receptor trapped clone 27 protein antibody; ART 27 antibody; ART-27 antibody; OTTHUMP00000023226 antibody; OTTHUMP00000023227 antibody; Protein UXT antibody; SKP2 associated alpha PFD 1 antibody; STAP1 antibody; Ubiquitously expressed prefoldin like chaperone antibody; Ubiquitously expressed transcript antibody; Ubiquitously expressed transcript protein antibody; Uxt antibody; UXT_HUMAN antibody

Product Type:Polyclonal Antibody

Immunogen Species:Homo sapiens (Human)

UniProt ID:Q9UBK9

Immunogen:Recombinant Human Protein UXT protein (1-157AA)

Raised in:Rabbit

Species Reactivity:Human

Tested Applications:ELISA, IHC; Recommended dilution: IHC:1:20-1:200

Background:Involved in gene transcription regulation. Acts in concert with the corepressor URI1 to regulate androgen receptor transcription (AR). AR N-terminus-associated coactivator which may play a role in facilitating receptor-induced transcriptional activation (PubMed:11854421). Potential component of mitochondrial-associated LRPPRC, a multidomain organizer that potentially integrates mitochondria and the microtubular cytoskeleton with chromosome remodeling (PubMed:11827465). Increasing concentrations of UXT contributes to progressive aggregation of mitochondria and cell death potentially through its association with LRPPRC (PubMed:17554592). May be a nuclear chaperone that promotes formation of the NF-kappa-B enhanceosome and which is essential for its nuclear function (PubMed:17620405). Suppresses cell transformation and it might mediate this function by interaction and inhibition of the biological activity of cell proliferation and survival stimulatory factors like MECOM (PubMed:17635584). Together with URI1, associates with chromatin to the NKX3-1 promoter region.

Clonality:Polyclonal

Isotype:IgG

Purification Method:Antigen Affinity Purified

Conjugate:Non-conjugated

Buffer:PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Form:Liquid

Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names:UXT

Research Areas:Epigenetics and Nuclear Signaling; Cancer; Signal transduction