USP2 Antibody - Cat. #: CSB-PA025710LA01HU

SKU: CSB-PA025710LA01HU

Size :50ug

Clone Number:

Aliases:41 kDa ubiquitin specific protease antibody; 41 kDa ubiquitin-specific protease antibody; Deubiquitinating enzyme 2 antibody; Ubiquitin carboxyl terminal hydrolase 2 antibody; Ubiquitin carboxyl-terminal hydrolase 2 antibody; ubiquitin specific peptidase 2 antibody; Ubiquitin specific processing protease 2 antibody; Ubiquitin specific protease 12 antibody; Ubiquitin specific protease 9 antibody; Ubiquitin specific protease, 41kD antibody; Ubiquitin thioesterase 2 antibody; Ubiquitin thiolesterase 2 antibody; Ubiquitin-specific-processing protease 2 antibody; Ubiquitin-specific-processing protease testis antibody; UBP-t antibody; UBP2_HUMAN antibody; UBP41 antibody; USP2 antibody; USP9 antibody

Product Type:Polyclonal Antibody

Immunogen Species:Homo sapiens (Human)

UniProt ID:O75604

Immunogen:Recombinant Human Ubiquitin carboxyl-terminal hydrolase 2 protein (9-265AA)

Raised in:Rabbit

Species Reactivity:Human

Tested Applications:ELISA, IF; Recommended dilution: IF:1:50-1:200

Background:Hydrolase that deubiquitinates polyubiquitinated target proteins such as MDM2, MDM4 and CCND1. Isoform 1 and isoform 4 possess both ubiquitin-specific peptidase and isopeptidase activities. Deubiquitinates MDM2 without reversing MDM2-mediated p53/TP53 ubiquitination and thus indirectly promotes p53/TP53 degradation and limits p53 activity. Has no deubiquitinase activity against p53/TP53. Prevents MDM2-mediated degradation of MDM4. Plays a role in the G1/S cell-cycle progression in normal and cancer cells. Plays a role in the regulation of myogenic differentiation of embryonic muscle cells. Regulates the circadian clock by modulating its intrinsic circadian rhythm and its capacity to respond to external cues. Associates with clock proteins and deubiquitinates core clock component PER1 but does not affect its overall stability. Regulates the nucleocytoplasmic shuttling and nuclear retention of PER1 and its repressive role on the clock transcription factors CLOCK and ARNTL/BMAL1 (By similarity).

Clonality:Polyclonal

Isotype:IgG

Purification Method:>95%, Protein G purified

Conjugate:Non-conjugated

Buffer:Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form:Liquid

Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names:USP2

Research Areas:Epigenetics and Nuclear Signaling; Cell biology