ULBP1 antibody , Cat. # FNab09249

SKU: FNab09249

Size:100ug

Purification:Immunogen affinity purified

Form:liquid

Purity:?95% as determined by SDS-PAGE

Host:Rabbit

Clonality:polyclonal

Clone ID:

Isotype:IgG

Storage:PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20? for 12 months(Avoid repeated freeze / thaw cycles.)

Background:Ligand for the KLRK1/NKG2D receptor, together with at least ULBP2 and ULBP3. ULBPs activate multiple signaling pathways in primary NK cells, resulting in the production of cytokines and chemokines. Binding of ULBPs ligands to KLRK1/NKG2D induces calcium mobilization and activation of the JAK2, STAT5, ERK and PI3K kinase/Akt signal transduction pathway. In CMV infected cells, interacts with soluble CMV glycoprotein UL16. The interaction with UL16 blocked the interaction with the KLRK1/NKG2D receptor, providing a mechanism by which CMV infected cells might escape the immune system. UL16 also causes ULBP1 to be retained in the ER and cis-Golgi apparatus so that it does not reach the cell surface.

Immunogen:UL16 binding protein 1

Synonyms:ALCAN beta, N2DL 1, N2DL1, NKG2D ligand 1, NKG2DL1, RAET1I, UL16 binding protein 1, ULBP1

Observed MW:30 kDa, 37 kDa

Uniprot ID:Q9BZM6

Reactivity:Human, Mouse

Tested Application:ELISA, WB, IHC

Recommended dilution:WB: 1:200-1:2000; IHC: 1?20-1?200

Gene ID:80329

Research Area:Cancer