UD11 Rabbit Polyclonal Antibody

SKU: BT-AP05385

Size:100μL

Background:This gene encodes a UDP-glucuronosyltransferase| an enzyme of the glucuronidation pathway that transforms small lipophilic molecules| such as steroids| bilirubin| hormones| and drugs| into water-soluble| excretable metabolites. This gene is part of a complex locus that encodes several UDP-glucuronosyltransferases. The locus includes thirteen unique alternate first exons followed by four common exons. Four of the alternate first exons are considered pseudogenes. Each of the remaining nine 5' exons may be spliced to the four common exons| resulting in nine proteins with different N-termini and identical C-termini. Each first exon encodes the substrate binding site| and is regulated by its own promoter. The preferred substrate of this enzyme is bilirubin| although it also has moderate activity with simple phenols| flavones| and C18 steroids. Mutations in this gene result in Crigler-Najjar syndromes types I and II and in Gilbert syndrome.

Research_area:Metabolism; Signal Transduction

Target_protein:UGT1A1

applications:WB

Reactivity:Human, Mouse, Rat

Clonality:Polyclonal

Clone ID:

Host:Rabbit

Isotype:IgG

Gene Symbol/ Name:UD11

Immunogen:The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189

Storage:-20°C for 1 year

Purification:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Formulation:Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration:1 mg/ml

Molecular weight(Da):58630

UniProt accession:Human: P22309; Mouse: Q63886; Rat: Q64550

Synonyms:UD11

GeneID:Human: 54658; Mouse: 394436; Rat: 24861