UBR2 antibody , Cat. # FNab09209

SKU: FNab09209

Size:100ug

Purification:Immunogen affinity purified

Form:liquid

Purity:?95% as determined by SDS-PAGE

Host:Rabbit

Clonality:polyclonal

Clone ID:

Isotype:IgG

Storage:PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20? for 12 months(Avoid repeated freeze / thaw cycles.)

Background:E3 ubiquitin-protein ligase which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. Plays a critical role in chromatin inactivation and chromosome-wide transcriptional silencing during meiosis via ubiquitination of histone H2A. Binds leucine and is a negative regulator of the leucine-mTOR signaling pathway, thereby controlling cell growth.

Immunogen:ubiquitin protein ligase E3 component n-recognin 2

Synonyms:BA49A4.1, C6orf133, dJ242G1.1, dJ392M17.3, DKFZp686C08114, KIAA0349, N recognin 2, RP3 392M17.3, UBR2

Observed MW:66 kDa

Uniprot ID:Q8IWV8

Reactivity:Human, Mouse

Tested Application:ELISA, WB, IF, IHC

Recommended dilution:WB: 1:200-1:2000; IF?1?10-1:100; IHC: 1:20-1:200

Gene ID:23304

Research Area:Epigenetics, Metabolism, Developmental biology