TYROBP Antibody - Cat. #: CSB-PA699424

SKU: CSB-PA699424

Size :50ul

Clone Number:

Aliases:DAP 12 antibody; DAP12 antibody; DNAX activation protein 12 antibody; DNAX-activation protein 12 antibody; KAR-associated protein antibody; KARAP antibody; Killer activating receptor associated protein antibody; Killer-activating receptor-associated protein antibody; PLOSL antibody; TYOBP_HUMAN antibody; TYRO protein tyrosine kinase binding protein antibody; TYRO protein tyrosine kinase-binding protein antibody; TYROBP antibody

Product Type:Polyclonal Antibody

Immunogen Species:Homo sapiens (Human)

UniProt ID:O43914

Immunogen:Synthetic peptide of Human TYROBP

Raised in:Rabbit

Species Reactivity:Human, Mouse, Rat

Tested Applications:ELISA, IHC; ELISA:1:1000-1:10000, IHC:1:25-1:100

Background:This gene encodes a transmembrane signaling polypeptide which contains an immunoreceptor tyrosine-based activation motif (ITAM) in its cytoplasmic domain. The encoded protein may associate with the killer-cell inhibitory receptor (KIR) family of membrane glycoproteins and may act as an activating signal transduction element. This protein may bind zeta-chain (TCR) associated protein kinase 70kDa (ZAP-70) and spleen tyrosine kinase (SYK) and play a role in signal transduction, bone modeling, brain myelination, and inflammation. Mutations within this gene have been associated with polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy (PLOSL), also known as Nasu-Hakola disease. Its putative receptor, triggering receptor expressed on myeloid cells 2 (TREM2), also causes PLOSL. Multiple alternative transcript variants encoding distinct isoforms have been identified for this gene.

Clonality:Polyclonal

Isotype:IgG

Purification Method:Antigen affinity purification

Conjugate:Non-conjugated

Buffer:-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol

Form:Liquid

Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names:TYROBP

Research Areas:Signal transduction