TUT1 Antibody - Cat. #: CSB-PA046708

SKU: CSB-PA046708

Size :100ul

Clone Number:

Aliases:alpha regulated poly(A) polymerase antibody; nuclear speckle targeted phosphatidylinositol 4 phosphate 5 kinase type I antibody; nuclear speckle targeted PIPK1A regulated poly(A) polymerase antibody; PAP associated domain containing 2 antibody; PAPD2 antibody; poly(A) polymerase associated domain containing 2 antibody; RBM21 antibody; RNA binding motif protein 21 antibody; RNA-binding motif protein 21 antibody; RNA-binding protein 21 antibody; Speckle targeted PIP5K1A-regulated poly(A) polymerase antibody; Star-PAP antibody; STARPAP antibody; STPAP_HUMAN antibody; terminal uridylyl transferase 1; U6 snRNA specific antibody; TUT1 antibody; TUTase antibody; U6 snRNA specific terminal uridylyltransferase 1 antibody; U6 snRNA-specific terminal uridylyltransferase 1 antibody; U6 TUTase antibody; U6-TUTase antibody; URLC6 antibody

Product Type:Polyclonal Antibody

Immunogen Species:Homo sapiens (Human)

UniProt ID:Q9H6E5

Immunogen:Synthesized peptide derived from internal of Human TUT1.

Raised in:Rabbit

Species Reactivity:Human

Tested Applications:ELISA, WB, IHC; WB:1:500-1:3000, IHC:1:50-1:100

Background:Poly(A) polymerase that creates the 3'-poly(A) tail of specific pre-mRNAs. Localizes to nuclear speckles together with PIP5K1A and mediates polyadenylation of a select set of mRNAs, such as HMOX1. In addition to polyadenylation, it is also required for the 3'-end cleavage of pre-mRNAs: binds to the 3'UTR of targeted pre-mRNAs and promotes the recruitment and assembly of the CPSF complex on the 3'UTR of pre-mRNAs. In addition to adenylyltransferase activity, also has uridylyltransferase activity. However, the ATP ratio is higher than UTP in cells, suggesting that it functions primarily as a poly(A) polymerase. Acts as a specific terminal uridylyltransferase for U6 snRNA in vitro: responsible for a controlled elongation reaction that results in the restoration of the four 3'-terminal UMP-residues found in newly transcribed U6 snRNA. Not involved in replication-dependent histone mRNA degradation.

Ota T., Nat. Genet. 36:40-45(2004).
The MGC Project Team, Genome Res. 14:2121-2127(2004).
Trippe R.,RNA 12:1494-1504(2006).

Clonality:Polyclonal

Isotype:IgG

Purification Method:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Conjugate:Non-conjugated

Buffer:Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Form:liquid

Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names:TUT1

Research Areas:Epigenetics and Nuclear Signaling