TTRAP antibody , Cat. # FNab09098

SKU: FNab09098

Size:100ug

Purification:Immunogen affinity purified

Form:liquid

Purity:?95% as determined by SDS-PAGE

Host:Rabbit

Clonality:polyclonal

Clone ID:

Isotype:IgG

Storage:PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20? for 12 months(Avoid repeated freeze / thaw cycles.)

Background:TTRAP is a 5-prime tyrosyl-DNA phosphodiesterase that is required for efficient repair of topoisomerase II-induced DNA double-strand breaks. Thus it can remove lots of covalent adducts from DNA through hydrolysis of a 5'-phosphodiester bond, generating a free 5' phosphate to DNA. It also has 3'-tyrosyl DNA phophodiesterase activity, but not so efficient as TDP1. TTRAP functions as a negative regulator of ETS1 and inhibit nuclear factor-kappa-B activation.

Immunogen:TRAF and TNF receptor associated protein

Synonyms:5 Tyr DNA phosphodiesterase, AD022, dJ30M3.3, EAP2, EAPII, ETS1 associated protein 2, ETS1 associated protein II, TDP2, TTRAP, Tyr DNA phosphodiesterase 2

Observed MW:44 kDa

Uniprot ID:O95551

Reactivity:Human, Mouse, Rat

Tested Application:ELISA, WB, IP

Recommended dilution:WB: 1:500-1:5000; IP: 1:200-1:2000

Gene ID:

Research Area:Signal Transduction