TRPV4 Antibody - Cat. #: CSB-PA881015ESR1HU

SKU: CSB-PA881015ESR1HU

Size :50ul

Clone Number:

Aliases:BCYM3 antibody; CMT2C antibody; HMSN2C antibody; osm 9 like TRP channel 4 antibody; Osm-9-like TRP channel 4 antibody; OSM9 like transient receptor potential channel 4 antibody; Osmosensitive transient receptor potential channel 4 antibody; OTRPC 4 antibody; OTRPC4 antibody; SMAL antibody; SPSMA antibody; SSQTL1 antibody; Transient receptor potential cation channel subfamily V member 4 antibody; Transient receptor potential protein 12 antibody; TRP 12 antibody; TRP12 antibody; TRPV 4 antibody; TrpV4 antibody; TRPV4_HUMAN antibody; Vanilloid receptor like channel 2 antibody; Vanilloid receptor like protein 2 antibody; Vanilloid receptor related osmotically activated channel antibody; Vanilloid receptor-like channel 2 antibody; Vanilloid receptor-like protein 2 antibody; Vanilloid receptor-related osmotically-activated channel antibody; VR 4 antibody; VR OAC antibody; VR-OAC antibody; VR4 antibody; VRL 2 antibody; VRL-2 antibody; VRL2 antibody; VROAC antibody

Product Type:Polyclonal Antibody

Immunogen Species:Homo sapiens (Human)

UniProt ID:Q9HBA0

Immunogen:Recombinant Human Transient receptor potential cation channel subfamily V member 4 protein (1-230AA)

Raised in:Rabbit

Species Reactivity:Human

Tested Applications:ELISA, IHC; Recommended dilution: IHC:1:20-1:200

Background:Non-selective calcium permeant cation channel probably involved in osmotic sensitivity and mechanosensitivity. Activation by exposure to hypotonicity within the physiological range exhibits an outward rectification. Also activated by low pH, citrate and phorbol esters. Increase of intracellular Ca2+ potentiates currents. Channel activity seems to be regulated by a calmodulin-dependent mechanism with a negative feedback mechanism. Promotes cell-cell junction formation in skin keratinocytes and plays an important role in the formation and/or maintenance of functional intercellular barriers. Acts as a regulator of intracellular Ca2+ in synoviocytes. Plays an obligatory role as a molecular component in the nonselective cation channel activation induced by 4-alpha-phorbol 12,13-didecanoate and hypotonic stimulation in synoviocytes and also regulates production of IL-8.

Clonality:Polyclonal

Isotype:IgG

Purification Method:Antigen Affinity Purified

Conjugate:Non-conjugated

Buffer:PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Form:Liquid

Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names:TRPV4

Research Areas:Neuroscience