TRIM63 antibody , Cat. # FNab08992

SKU: FNab08992

Size:100ug

Purification:Immunogen affinity purified

Form:liquid

Purity:?95% as determined by SDS-PAGE

Host:Rabbit

Clonality:polyclonal

Clone ID:

Isotype:IgG

Storage:PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20? for 12 months(Avoid repeated freeze / thaw cycles.)

Background:E3 ubiquitin ligase. Mediates the ubiquitination and subsequent proteasomal degradation of CKM, GMEB1 and HIBADH. Regulates the proteasomal degradation of muscle proteins under amino acid starvation, where muscle protein is catabolized to provide other organs with amino acids. Inhibits de novo skeletal muscle protein synthesis under amino acid starvation. Regulates proteasomal degradation of cardiac troponin I/TNNI3 and probably of other sarcomeric-associated proteins. May play a role in striated muscle atrophy and hypertrophy by regulating an anti-hypertrophic PKC-mediated signaling pathway. May regulate the organization of myofibrils through TTN in muscle cells.

Immunogen:tripartite motif-containing 63

Synonyms:FLJ32380, IRF, Iris RING finger protein, MuRF 1, MURF1, MURF2, RING finger protein 28, RNF28, SMRZ, TRIM63, tripartite motif containing 63

Observed MW:40 kDa

Uniprot ID:Q969Q1

Reactivity:Human, Mouse, Rat

Tested Application:ELISA, WB, IHC, IF

Recommended dilution:WB: 1:200-1:1000; IHC: 1:20-1:200; IF: 1:10-1:100

Gene ID:84676

Research Area:Epigenetics, Cardiovascular, Metabolism, Signal Transduction