Trim21 Antibody, HRP conjugated - Cat. #: CSB-PA733816LB01MO

SKU: CSB-PA733816LB01MO

Size :50ug

Clone Number:

Aliases:Trim21 antibody; Ro52 antibody; Ssa1 antibody; E3 ubiquitin-protein ligase TRIM21 antibody; EC 2.3.2.27 antibody; 52 kDa Ro protein antibody; 52 kDa ribonucleoprotein autoantigen Ro/SS-A antibody; RING-type E3 ubiquitin transferase TRIM21 antibody; Ro(SS-A) antibody; Sjoegren syndrome type A antigen antibody; SS-A antibody; Tripartite motif-containing protein 21 antibody

Product Type:Polyclonal Antibody

Immunogen Species:Mus musculus (Mouse)

UniProt ID:Q62191

Immunogen:Recombinant Mouse E3 ubiquitin-protein ligase TRIM21 protein (1-470AA)

Raised in:Rabbit

Species Reactivity:Mouse

Tested Applications:ELISA

Background:E3 ubiquitin-protein ligase whose activity is dependent on E2 enzymes, UBE2D1, UBE2D2, UBE2E1 and UBE2E2. Forms a ubiquitin ligase complex in cooperation with the E2 UBE2D2 that is used not only for the ubiquitination of USP4 and IKBKB but also for its self-ubiquitination. Component of cullin-RING-based SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes such as SCF(SKP2)-like complexes. A TRIM21-containing SCF(SKP2)-like complex is shown to mediate ubiquitination of CDKN1B (\'Thr-187\' phosphorylated-form), thereby promoting its degradation by the proteasome. Monoubiquitinates IKBKB that will negatively regulates Tax-induced NF-kappa-B signaling. Negatively regulates IFN-beta production post-pathogen recognition by polyubiquitin-mediated degradation of IRF3. Mediates the ubiquitin-mediated proteasomal degradation of IgG1 heavy chain, which is linked to the VCP-mediated ER-associated degradation (ERAD) pathway. Promotes IRF8 ubiquitination, which enhanced the ability of IRF8 to stimulate cytokine genes transcription in macrophages. Plays a role in the regulation of the cell cycle progression. Enhances the decapping activity of DCP2. Exists as a ribonucleoprotein particle present in all mammalian cells studied and composed of a single polypeptide and one of four small RNA molecules. At least two isoforms are present in nucleated and red blood cells, and tissue specific differences in RO/SSA proteins have been identified. The common feature of these proteins is their ability to bind HY RNAs.2.

Clonality:Polyclonal

Isotype:IgG

Purification Method:>95%, Protein G purified

Conjugate:HRP

Buffer:Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form:Liquid

Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names:Trim21

Research Areas:Others