TREX1 Antibody - Cat. #: CSB-PA865133ESR2HU

SKU: CSB-PA865133ESR2HU

Size :50ul

Clone Number:

Aliases:TREX1 antibody; Three-prime repair exonuclease 1 antibody; EC 3.1.11.2 antibody; 3'-5' exonuclease TREX1 antibody; Deoxyribonuclease III antibody; DNase III antibody

Product Type:Polyclonal Antibody

Immunogen Species:Homo sapiens (Human)

UniProt ID:Q9NSU2

Immunogen:Recombinant Human Three-prime repair exonuclease 1 protein (1-270AA)

Raised in:Rabbit

Species Reactivity:Human

Tested Applications:ELISA, IHC; Recommended dilution: IHC:1:20-1:200

Background:Major cellular 3\\\'-to-5\\\' DNA exonuclease which digests single-stranded DNA (ssDNA) and double-stranded DNA (dsDNA) with mismatched 3\\\' termini. Prevents cell-intrinsic initiation of autoimmunity. Acts by metabolizing DNA fragments from endogenous retroelements, including L1, LTR and SINE elements. Unless degraded, these DNA fragments accumulate in the cytosol and activate the IFN-stimulatory DNA (ISD) response and innate immune signaling. Prevents chronic ATM-dependent checkpoint activation, by processing ssDNA polynucleotide species arising from the processing of aberrant DNA replication intermediates. Inefficiently degrades oxidized DNA, such as that generated upon antimicrobial reactive oxygen production or upon absorption of UV light. During GZMA-mediated cell death, contributes to DNA damage in concert with NME1. NME1 nicks one strand of DNA and TREX1 removes bases from the free 3\\\' end to enhance DNA damage and prevent DNA end reannealing and rapid repair.

Clonality:Polyclonal

Isotype:IgG

Purification Method:Antigen Affinity Purified

Conjugate:Non-conjugated

Buffer:PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Form:Liquid

Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names:TREX1

Research Areas:Epigenetics and Nuclear Signaling; Immunology