TOR1A Antibody - Cat. #: CSB-PA024067LA01HU

SKU: CSB-PA024067LA01HU

Size :50ug

Clone Number:

Aliases:DQ2 antibody; Dystonia 1 antibody; Dystonia 1 protein antibody; Dystonia 1 torsion antibody; Dyt1 antibody; TOR1A antibody; TOR1A_HUMAN antibody; Torsin 1A antibody; Torsin A antibody; Torsin family 1 member A antibody; Torsin family 1, member A (torsin A) antibody; Torsin-1A antibody

Product Type:Polyclonal Antibody

Immunogen Species:Homo sapiens (Human)

UniProt ID:O14656

Immunogen:Recombinant Human Torsin-1A protein (88-125AA)

Raised in:Rabbit

Species Reactivity:Human

Tested Applications:ELISA, IHC, IF; Recommended dilution: IHC:1:20-1:200, IF:1:50-1:200

Background:Protein with chaperone functions important for the control of protein folding, processing, stability and localization as well as for the reduction of misfolded protein aggregates. Involved in the regulation of synaptic vesicle recycling, controls STON2 protein stability in collaboration with the COP9 signalosome complex (CSN). In the nucleus, may link the cytoskeleton with the nuclear envelope, this mechanism seems to be crucial for the control of nuclear polarity, cell movement and, specifically in neurons, nuclear envelope integrity. Participates in the cellular trafficking and may regulate the subcellular location of multipass membrane proteins such as the dopamine transporter SLC6A3, leading to the modulation of dopamine neurotransmission. In the endoplasmic reticulum, plays a role in the quality control of protein folding by increasing clearance of misfolded proteins such as SGCE variants or holding them in an intermediate state for proper refolding. May have a redundant function with TOR1B in non-neural tissues.

Clonality:Polyclonal

Isotype:IgG

Purification Method:>95%, Protein G purified

Conjugate:Non-conjugated

Buffer:Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form:Liquid

Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names:TOR1A

Research Areas:Neuroscience