TOP2A(Phospho Ser1213) Rabbit Polyclonal Antibody

SKU: BT-AP13123

Size:100μL

Background:Catalytic activity:ATP-dependent breakage| passage and rejoining of double-stranded DNA.|enzyme regulation:Specifically inhibited by the intercalating agent amsacrine.|Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double-strand breaks.|miscellaneous:Eukaryotic topoisomerase I and II can relax both negative and positive supercoils| whereas prokaryotic enzymes relax only negative supercoils.|PTM:Phosphorylation has no effect on Catalytic activity.|Belongs to the type II topoisomerase family.|subcellular location:Generally located in the nucleoplasm.|subunit:Homodimer. Interacts with COPS5.|

Research_area:Epigenetics and nuclear signaling; Cancer

Target_protein:TOP2A

applications:WB, ELISA

Reactivity:Human, Rat, Mouse

Clonality:Polyclonal

Clone ID:

Host:Rabbit

Isotype:IgG

Gene Symbol/ Name:TOP2A

Immunogen:The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189

Storage:-20°C for 1 year

Purification:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Formulation:Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration:1 mg/ml

Molecular weight(Da):168410

UniProt accession:Human: P11388; Mouse: Q01320; Rat: P41516

Synonyms:TOP2A ;Phospho Ser1213; DNA topoisomerase 2-alpha; EC 5.99.1.3; DNA topoisomerase II; alpha isozyme

GeneID:Human: 7153; Mouse: 21973; Rat: 360243