TOLLIP Antibody, FITC conjugated - Cat. #: CSB-PA875640LC01HU

SKU: CSB-PA875640LC01HU

Size :50ug

Clone Number:

Aliases:Adapter protein antibody; FLJ33531 antibody; IL 1RAcPIP antibody; IL1RAcPIP antibody; TOLIP antibody; TOLIP_HUMAN antibody; Toll interacting protein antibody; Toll-interacting protein antibody; tollip antibody

Product Type:Polyclonal Antibody

Immunogen Species:Homo sapiens (Human)

UniProt ID:Q9H0E2

Immunogen:Recombinant Human Toll-interacting protein (86-163AA)

Raised in:Rabbit

Species Reactivity:Human

Tested Applications:

Background:Component of the signaling pathway of IL-1 and Toll-like receptors. Inhibits cell activation by microbial products. Recruits IRAK1 to the IL-1 receptor complex. Inhibits IRAK1 phosphorylation and kinase activity (PubMed:11751856). Connects the ubiquitin pathway to autophagy by functioning as a ubiquitin-ATG8 family adapter and thus mediating autophagic clearance of ubiquitin conjugates. The TOLLIP-dependent selective autophagy pathway plays an important role in clearance of cytotoxic polyQ proteins aggregates (PubMed:25042851).

Clonality:Polyclonal

Isotype:IgG

Purification Method:>95%, Protein G purified

Conjugate:FITC

Buffer:Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form:Liquid

Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names:TOLLIP

Research Areas:Immunology