TLR3 Antibody - Cat. #: CSB-PA191967

SKU: CSB-PA191967

Size :50ul

Clone Number:

Aliases:CD283 antibody; CD283 antigen antibody; IIAE2 antibody; TLR 3 antibody; Tlr3 antibody; TLR3_HUMAN antibody; Toll Like Receptor 3 antibody; Toll-like receptor 3 antibody

Product Type:Polyclonal Antibody

Immunogen Species:Homo sapiens (Human)

UniProt ID:O15455

Immunogen:Fusion protein of Human TLR3

Raised in:Rabbit

Species Reactivity:Human, Mouse

Tested Applications:ELISA, WB; ELISA:1:2000-1:5000, WB:1:500-1:2000

Background:The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This receptor is most abundantly expressed in placenta and pancreas, and is restricted to the dendritic subpopulation of the leukocytes. It recognizes dsRNA associated with viral infection, and induces the activation of NF-kappaB and the production of type I interferons. It may thus play a role in host defense against viruses. Use of alternative polyadenylation sites to generate different length transcripts has been noted for this gene.

Clonality:Polyclonal

Isotype:IgG

Purification Method:Antigen affinity purification

Conjugate:Non-conjugated

Buffer:-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol

Form:Liquid

Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names:TLR3

Research Areas:Immunology;Microbiology?Signal transduction