TCEB2 antibody , Cat. # FNab08549

SKU: FNab08549

Size:100ug

Purification:Immunogen affinity purified

Form:liquid

Purity:?95% as determined by SDS-PAGE

Host:Rabbit

Clonality:polyclonal

Clone ID:

Isotype:IgG

Storage:PBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20? for 12 months (Avoid repeated freeze / thaw cycles.)

Background:This gene encodes the protein elongin B, which is a subunit of the transcription factor B (SIII) complex. The SIII complex is composed of elongins A/A2, B and C. It activates elongation by RNA polymerase II by suppressing transient pausing of the polymerase at many sites within transcription units. Elongin A functions as the transcriptionally active component of the SIII complex, whereas elongins B and C are regulatory subunits. Elongin A2 is specifically expressed in the testis, and capable of forming a stable complex with elongins B and C. The von Hippel-Lindau tumor suppressor protein binds to elongins B and C, and thereby inhibits transcription elongation. Two alternatively spliced transcript variants encoding different isoforms have been described for this gene. Pseudogenes have been identified on chromosomes 11 and 13.

Immunogen:transcription elongation factor B (SIII), polypeptide 2 (18kDa, elongin B)

Synonyms:

Observed MW:16 kDa

Uniprot ID:Q15370

Reactivity:Human

Tested Application:ELISA, WB, IHC, IP

Recommended dilution:WB: 1:500 - 1:2000; IHC: 1:50 - 1:200; IP: 1:20 - 1:50

Gene ID:6923

Research Area:Metabolism