TBK1 Antibody, FITC conjugated - Cat. #: CSB-PA023232LC01HU

SKU: CSB-PA023232LC01HU

Size :50ug

Clone Number:

Aliases:EC 2.7.11.1 antibody; FLJ11330 antibody; FTDALS4 antibody; NAK antibody; NF kappa B activating kinase antibody; NF kB activating kinase antibody; NF-kappa-B-activating kinase antibody; Serine/threonine protein kinase TBK 1 antibody; Serine/threonine protein kinase TBK1 antibody; Serine/threonine-protein kinase TBK1 antibody; T2K antibody; TANK binding kinase 1 antibody; TANK-binding kinase 1 antibody; TBK 1 antibody; Tbk1 antibody; TBK1_HUMAN antibody

Product Type:Polyclonal Antibody

Immunogen Species:Homo sapiens (Human)

UniProt ID:Q9UHD2

Immunogen:Recombinant Human Serine/threonine-protein kinase TBK1 protein (364-585AA)

Raised in:Rabbit

Species Reactivity:Human

Tested Applications:

Background:Serine/threonine kinase that plays an essential role in regulating inflammatory responses to foreign agents. Following activation of toll-like receptors by viral or bacterial components, associates with TRAF3 and TANK and phosphorylates interferon regulatory factors (IRFs) IRF3 and IRF7 as well as DDX3X. This activity allows subsequent homodimerization and nuclear translocation of the IRFs leading to transcriptional activation of pro-inflammatory and antiviral genes including IFNA and IFNB. In order to establish such an antiviral state, TBK1 form several different complexes whose composition depends on the type of cell and cellular stimuli. Thus, several scaffolding molecules including FADD, TRADD, MAVS, AZI2, TANK or TBKBP1/SINTBAD can be recruited to the TBK1-containing-complexes. Under particular conditions, functions as a NF-kappa-B effector by phosphorylating NF-kappa-B inhibitor alpha/NFKBIA, IKBKB or RELA to translocate NF-Kappa-B to the nucleus. Restricts bacterial proliferation by phosphorylating the autophagy receptor OPTN/Optineurin on \'Ser-177\', thus enhancing LC3 binding affinity and antibacterial autophagy. Phosphorylates and activates AKT1. Seems to play a role in energy balance regulation by sustaining a state of chronic, low-grade inflammation in obesity, wich leads to a negative impact on insulin sensitivity. Attenuates retroviral budding by phosphorylating the endosomal sorting complex required for transport-I (ESCRT-I) subunit VPS37C. Phosphorylates Borna disease virus (BDV) P protein.

Clonality:Polyclonal

Isotype:IgG

Purification Method:>95%, Protein G purified

Conjugate:FITC

Buffer:Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form:Liquid

Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names:TBK1

Research Areas:Epigenetics and Nuclear Signaling; Signal transduction