SYNE2 Antibody, Biotin conjugated - Cat. #: CSB-PA841001LD01HU

SKU: CSB-PA841001LD01HU

Size :50ug

Clone Number:

Aliases:DKFZP434H2235 antibody; DKFZp686E01115 antibody; DKFZp686H1931 antibody; FLJ11014 antibody; FLJ43727 antibody; FLJ45710 antibody; FLJ46790 antibody; KIAA1011 antibody; Nesprin-2 antibody; Nesprin2 antibody; NUA antibody; NUANCE antibody; Nuclear envelope spectrin repeat protein 2 antibody; Nucleus and actin connecting element antibody; Nucleus and actin connecting element protein antibody; Protein NUANCE antibody; Spectrin repeat containing nuclear envelope 2 antibody; Synaptic nuclear envelope protein 2 antibody; Synaptic nuclei expressed gene 2 antibody; SYNE 2 antibody; Syne-2 antibody; SYNE2 antibody; SYNE2_HUMAN antibody

Product Type:Polyclonal Antibody

Immunogen Species:Homo sapiens (Human)

UniProt ID:Q8WXH0

Immunogen:Recombinant Human Nesprin-2 protein (1-176AA)

Raised in:Rabbit

Species Reactivity:Human

Tested Applications:ELISA

Background:Multi-isomeric modular protein which forms a linking network between organelles and the actin cytoskeleton to maintain the subcellular spatial organization. As a component of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex involved in the connection between the nuclear lamina and the cytoskeleton. The nucleocytoplasmic interactions established by the LINC complex play an important role in the transmission of mechanical forces across the nuclear envelope and in nuclear movement and positioning. Specifically, SYNE2 and SUN2 assemble in arrays of transmembrane actin-associated nuclear (TAN) lines which are bound to F-actin cables and couple the nucleus to retrograde actin flow during actin-dependent nuclear movement. May be involved in nucleus-centrososme attachment. During interkinetic nuclear migration (INM) at G2 phase and nuclear migration in neural progenitors its LINC complex association with SUN1/2 and probable association with cytoplasmic dynein-dynactin motor complexes functions to pull the nucleus toward the centrosome; SYNE1 and SYNE2 may act redundantly. During INM at G1 phase mediates respective LINC complex association with kinesin to push the nucleus away from the centrosome. Involved in nuclear migration in retinal photoreceptor progenitors. Required for centrosome migration to the apical cell surface during early ciliogenesis.

Clonality:Polyclonal

Isotype:IgG

Purification Method:>95%, Protein G purified

Conjugate:Biotin

Buffer:Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form:Liquid

Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names:SYNE2

Research Areas:Tags & Cell Markers; Signal transduction