STK11 Monoclonal Antibody

SKU: BT-MCA4776

Size:100μL

Background:Essential role in G1 cell cycle arrest. Phosphorylates and activates members of the AMPK-related subfamily of protein kinases. Tumor suppressor.serine/threonine kinase 11,with two alternatively spliced isoforms,expressed in all tissues,strongly homolog of Xenopus early embryonic kinase 1 (XEEK1),tumor suppressor gene in hamartomas syndrome and in left sided colon carcinogenesis,mutated in sporadic testicular cancer,malignant melanomas and laryngeal tumors,playing a minor role in the development of ovarian carcinoma.LKB1 is a potential target for atherosclerosis and cancer and is shown to be mutated in patients with Peutz-Jeghers cancer syndrome. Tissue specificity: Ubiquitously expressed. Strongest expression in testis and fetal liver.

Research_area:Cell Biology

Target_protein:STK11

applications:WB, FCM

Reactivity:Human, Mouse, Monkey

Clonality:Monoclonal

Clone ID:4H12

Host:Mouse

Isotype:Mouse IgG1

Gene Symbol/ Name:STK11

Immunogen:Purified recombinant fragment of human STK11 expressed in E. Coli.

Storage:4°C|-20°C for long term storage

Purification:

Formulation:Ascitic fluid containing 0.03% sodium azide.

Concentration:

Molecular weight(Da):54kDa

UniProt accession:Q15831

Synonyms:PJS, LKB1, STK11

GeneID:6794