STIM1 Antibody, Biotin conjugated - Cat. #: CSB-PA022829LD01HU

SKU: CSB-PA022829LD01HU

Size :50ug

Clone Number:

Aliases:D11S4896E antibody; GOK antibody; OTTHUMP00000164512 antibody; OTTHUMP00000229140 antibody; OTTHUMP00000230742 antibody; SIM antibody; STIM 1 antibody; STIM1 antibody; Stim1 stromal interaction molecule 1 antibody; STIM1_HUMAN antibody; STIM1L antibody; Stromal interaction molecule 1 antibody

Product Type:Polyclonal Antibody

Immunogen Species:Homo sapiens (Human)

UniProt ID:Q13586

Immunogen:Recombinant Human Stromal interaction molecule 1 protein (2-350AA)

Raised in:Rabbit

Species Reactivity:Human

Tested Applications:ELISA

Background:Plays a role in mediating store-operated Ca(2+) entry (SOCE), a Ca(2+) influx following depletion of intracellular Ca(2+) stores (PubMed:15866891, PubMed:16005298, PubMed:16208375, PubMed:16537481, PubMed:16733527, PubMed:16766533, PubMed:16807233, PubMed:18854159, PubMed:19249086, PubMed:22464749, PubMed:24069340, PubMed:24351972, PubMed:24591628, PubMed:26322679, PubMed:25326555). Acts as Ca(2+) sensor in the endoplasmic reticulum via its EF-hand domain. Upon Ca(2+) depletion, translocates from the endoplasmic reticulum to the plasma membrane where it activates the Ca(2+) release-activated Ca(2+) (CRAC) channel subunit ORAI1 (PubMed:16208375, PubMed:16537481). Involved in enamel formation (PubMed:24621671). Activated following interaction with TMEM110/STIMATE, leading to promote STIM1 conformational switch (PubMed:26322679).

Clonality:Polyclonal

Isotype:IgG

Purification Method:>95%, Protein G purified

Conjugate:Biotin

Buffer:Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form:Liquid

Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names:STIM1

Research Areas:Cancer; Metabolism; Signal transduction