SPIN1 Antibody - Cat. #: CSB-PA897305DSR1HU

SKU: CSB-PA897305DSR1HU

Size :50ul

Clone Number:

Aliases:OCR antibody; Ovarian cancer-related protein antibody; SPIN antibody; Spin1 antibody; SPIN1_HUMAN antibody; Spindlin-1 antibody

Product Type:Polyclonal Antibody

Immunogen Species:Homo sapiens (Human)

UniProt ID:Q9Y657

Immunogen:Recombinant Human Spindlin-1 protein (1-262AA)

Raised in:Rabbit

Species Reactivity:Human

Tested Applications:ELISA, WB, IHC; Recommended dilution: WB:1:1000-1:5000, IHC:1:20-1:200

Background:Chromatin reader that specifically recognizes and binds histone H3 both trimethylated at \\\'Lys-4\\\' and asymmetrically dimethylated at \\\'Arg-8\\\' (H3K4me3 and H3R8me2a) and acts as an activator of Wnt signaling pathway dowstream of PRMT2. In case of cancer, promotes cell cancer proliferation via activation of the Wnt signaling pathway (PubMed:24589551). Overexpression induces metaphase arrest and chromosomal instability. Localizes to active rDNA loci and promotes the expression of rRNA genes (PubMed:21960006). May play a role in cell-cycle regulation during the transition from gamete to embryo. Involved in oocyte meiotic resumption, a process that takes place before ovulation to resume meiosis of oocytes blocked in prophase I: may act by regulating maternal transcripts to control meiotic resumption.

Clonality:Polyclonal

Isotype:IgG

Purification Method:Antigen Affinity Purified

Conjugate:Non-conjugated

Buffer:PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Form:Liquid

Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names:SPIN1

Research Areas:Epigenetics and Nuclear Signaling; Cancer; Cell biology; Developmental biology