SMUG1 Antibody - Cat. #: CSB-PA897931

SKU: CSB-PA897931

Size :100ul

Clone Number:

Aliases:FDG antibody; HMUDG antibody; MGC104370 antibody; Single strand selective monofunctional uracil DNA glycosylase 1 antibody; Single strand selective monofunctional uracil DNA glycosylase antibody; Single-strand selective monofunctional uracil DNA glycosylase antibody; SMUG 1 antibody; Smug1 antibody; SMUG1 protein antibody; SMUG1_HUMAN antibody; UNG 3 antibody; UNG3 antibody

Product Type:Polyclonal Antibody

Immunogen Species:Homo sapiens (Human)

UniProt ID:Q53HV7

Immunogen:Synthesized peptide derived from internal of Human SMUG1.

Raised in:Rabbit

Species Reactivity:Human

Tested Applications:ELISA, WB; WB:1:500-1:3000

Background:Responsible for recognizing base lesions in the genome and initiating base excision DNA repair. Acts as a monofunctional DNA glycosylase specific for uracil (U) residues in DNA and has a preference for single-stranded DNA substrates. The activity is greater against mismatches (U/G) than against matches (U/A). Excised uracil (U), 5-formyluracil (fU) and uracil derivatives bearing an oxidized group at C5 [5-hydroxyuracil (hoU) and 5-hydroxymethyluracil (hmU)] in ssDNA and dsDNA but not analogous cytosine derivatives (5-hydroxycytosine and 5-formylcytosine) and other oxidized damage. The activity is damage specificity and salt concentration-dependent. The general order of the preference for ssDNA and dsDNA is the following: ssDNA > dsDNA (G pair) = dsDNA (A pair) at the low salt concentration. At the high concentration dsDNA (G pair) > dsDNA (A pair) > ssDNA.

Ide H., Biochemistry 42:5003-5012(2003).
Sugano S., Nat. Genet. 36:40-45(2004).
Venter J.C., Submitted (JUL-2005).

Clonality:Polyclonal

Isotype:IgG

Purification Method:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Conjugate:Non-conjugated

Buffer:Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Form:liquid

Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names:SMUG1

Research Areas:Epigenetics and Nuclear Signaling