SMARCE1 Antibody, HRP conjugated - Cat. #: CSB-PA839275LB01HU

SKU: CSB-PA839275LB01HU

Size :50ug

Clone Number:

Aliases:BAF57 antibody; BRG1 associated factor 57 antibody; BRG1-associated factor 57 antibody; Chromatin remodeling complex BRG1 associated factor 57 antibody; FLJ35648 antibody; SMARCE 1 antibody; SMARCE1 antibody; SMCE1_HUMAN antibody; SWI/SNF related matrix associated actin dependent regulator of chromatin e1 antibody; SWI/SNF related matrix associated actin dependent regulator of chromatin subfamily e member 1 antibody; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1 antibody

Product Type:Polyclonal Antibody

Immunogen Species:Homo sapiens (Human)

UniProt ID:Q969G3

Immunogen:Recombinant Human SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1 protein (20-243AA)

Raised in:Rabbit

Species Reactivity:Human

Tested Applications:ELISA

Background:Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a post-mitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to post-mitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity). Required for the coactivation of estrogen responsive promoters by Swi/Snf complexes and the SRC/p160 family of histone acetyltransferases (HATs). Also specifically interacts with the CoREST corepressor resulting in repression of neuronal specific gene promoters in non-neuronal cells.

Clonality:Polyclonal

Isotype:IgG

Purification Method:>95%, Protein G purified

Conjugate:HRP

Buffer:Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form:Liquid

Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names:SMARCE1

Research Areas:Epigenetics and Nuclear Signaling