SIRT5 Antibody - Cat. #: CSB-PA873680LA01HU

SKU: CSB-PA873680LA01HU

Size :50ug

Clone Number:

Aliases:NAD dependent deacetylase sirtuin 5 antibody; NAD dependent lysine demalonylase and desuccinylase sirtuin 5 mitochondrial antibody; NAD dependent protein deacylase sirtuin 5 mitochondrial antibody; NAD-dependent protein deacylase sirtuin-5; mitochondrial antibody; Regulatory protein SIR2 homolog 5 antibody; Silent mating type information regulation 2 S.cerevisiae homolog 5 antibody; Sir2 like 5 antibody; SIR2-like protein 5 antibody; SIR2L5 antibody; SIR5_HUMAN antibody; Sirt5 antibody; Sirtuin 5 antibody; Sirtuin type 5 antibody

Product Type:Polyclonal Antibody

Immunogen Species:Homo sapiens (Human)

UniProt ID:Q9NXA8

Immunogen:Recombinant Human NAD-dependent protein deacylase sirtuin-5, mitochondrial protein (60-212AA)

Raised in:Rabbit

Species Reactivity:Human

Tested Applications:ELISA, IHC, IF; Recommended dilution: IHC:1:20-1:200, IF:1:50-1:200

Background:NAD-dependent lysine demalonylase, desuccinylase and deglutarylase that specifically removes malonyl, succinyl and glutaryl groups on target proteins (PubMed:21908771, PubMed:22076378, PubMed:24703693). Activates CPS1 and contributes to the regulation of blood ammonia levels during prolonged fasting: acts by mediating desuccinylation and deglutarylation of CPS1, thereby increasing CPS1 activity in response to elevated NAD levels during fasting (PubMed:22076378, PubMed:24703693). Activates SOD1 by mediating its desuccinylation, leading to reduced reactive oxygen species (PubMed:24140062). Modulates ketogenesis through the desuccinylation and activation of HMGCS2 (By similarity). Has weak NAD-dependent protein deacetylase activity; however this activity may not be physiologically relevant in vivo. Can deacetylate cytochrome c (CYCS) and a number of other proteins in vitro such as UOX.

Clonality:Polyclonal

Isotype:IgG

Purification Method:>95%, Protein G purified

Conjugate:Non-conjugated

Buffer:Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form:Liquid

Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names:SIRT5

Research Areas:Epigenetics and Nuclear Signaling; Cancer; Cardiovascular; Metabolism