SIN3A Antibody - Cat. #: CSB-RA242724A0HU

SKU: CSB-RA242724A0HU

Size :50ul

Clone Number:10G3

Aliases:Paired amphipathic helix protein Sin3a (Histone deacetylase complex subunit Sin3a) (Transcriptional corepressor Sin3a), SIN3A

Product Type:Recombinant Antibody

Immunogen Species:Homo sapiens (Human)

UniProt ID:Q96ST3

Immunogen:A synthesized peptide derived from human mSin3A

Raised in:

Species Reactivity:Human

Tested Applications:ELISA, WB, IHC, IF; Recommended dilution: WB:1:500-1:5000, IHC:1:50-1:200, IF:1:20-1:200

Background:Acts as a transcriptional repressor. Corepressor for REST. Interacts with MXI1 to repress MYC responsive genes and antagonize MYC oncogenic activities. Also interacts with MXD1-MAX heterodimers to repress transcription by tethering SIN3A to DNA. Acts cooperatively with OGT to repress transcription in parallel with histone deacetylation. Involved in he control of the circadian rhythms. Required for the transcriptional repression of circadian target genes, such as PER1, mediated by the large PER complex through histone deacetylation. Cooperates with FOXK1 to regulate cell cycle progression probably by repressing cell cycle inhibitor genes expression (By similarity).

Clonality:Monoclonal

Isotype:Rabbit IgG

Purification Method:Affinity-chromatography

Conjugate:Non-conjugated

Buffer:Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Form:Liquid

Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names:SIN3A

Research Areas:Epigenetics and Nuclear Signaling; Cancer; Metabolism