SIGLEC8 Monoclonal Antibody

SKU: BT-MCA4447

Size:100μL

Background:Sialic acid-binding immunoglobulin (Ig)-like lectins, or SIGLECs (e.g., CD33 (MIM 159590)), are a family of type 1 transmembrane proteins each having a unique expression pattern, mostly in hemopoietic cells. SIGLEC8 is a member of the CD33-like subgroup of SIGLECs, which are localized to 19q13.3-q13.4 and have 2 conserved cytoplasmic tyrosine-based motifs: an immunoreceptor tyrosine-based inhibitory motif, or ITIM (see MIM 604964), and a motif homologous to one identified in signaling lymphocyte activation molecule (SLAM; MIM 603492) that mediates an association with SLAM-associated protein (SAP; MIM 300490) (summarized by Foussias et al., 2000 [PubMed 11095983])

Research_area:Immunology

Target_protein:SIGLEC8

applications:WB, IHC, FCM

Reactivity:

Clonality:Monoclonal

Clone ID:1A5B9

Host:Mouse

Isotype:Mouse IgG2b

Gene Symbol/ Name:SIGLEC8

Immunogen:Purified recombinant fragment of human SIGLEC8 (AA: extra 17-216) expressed in E. Coli.

Storage:4°C|-20°C for long term storage

Purification:

Formulation:Purified antibody in PBS with 0.05% sodium azide

Concentration:

Molecular weight(Da):54kDa

UniProt accession:Q9NYZ4

Synonyms:SAF2, SIGLEC-8, SIGLEC8L

GeneID:27181