SIAH1 rabbit pAb

SKU: ES13109

Size: 100μL

Source:Rabbit

Applications:WB

Reactivity:Human;Rat

Dilution:WB 1：500-2000

Immunogen:Synthesized peptide derived from human SIAH1 AA range: 157-207

Storage_stability:-20°C/1 year

Clonality:Polyclonal

Isotype:IgG

Concentration:1 mg/ml

Observed_band(KD):

Human_gene_id:6477

Human_swiss_prot_no:Q8IUQ4

Subcellular_location:Cytoplasm. Nucleus. Predominantly cytoplasmic. Partially nuclear.

Other_name:

Background:This gene encodes a protein that is a member of the seven in absentia homolog (SIAH) family. The protein is an E3 ligase and is involved in ubiquitination and proteasome-mediated degradation of specific proteins. The activity of this ubiquitin ligase has been implicated in the development of certain forms of Parkinson's disease, the regulation of the cellular response to hypoxia and induction of apoptosis. Alternative splicing results in several additional transcript variants, some encoding different isoforms and others that have not been fully characterized. [provided by RefSeq, Jul 2008],