SCNNA Polyclonal Antibody

SKU: BT-AP14082

Size:100μL

Background:Nonvoltage-gated, amiloride-sensitive, sodium channels control fluid and electrolyte transport across epithelia in many organs. These channels are heteromeric complexes consisting of 3 subunits: alpha, beta, and gamma. This gene encodes the alpha subunit, and mutations in this gene have been associated with pseudohypoaldosteronism type 1 (PHA1), a rare salt wasting disease resulting from target organ unresponsiveness to mineralocorticoids. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.

Research_area:Neuroscience; Signal transduction; Metabolism

Target_protein:SCNN1A

applications:WB, ELISA

Reactivity:Human, Mouse, Rat

Clonality:Polyclonal

Clone ID:

Host:Rabbit

Isotype:IgG

Gene Symbol/ Name:Amiloride-sensitive sodium channel subunit alpha

Immunogen:The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189

Storage:-20°C for 1 year

Purification:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Formulation:Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration:1 mg/ml

Molecular weight(Da):

UniProt accession:Human: P37088; Mouse: Q61180; Rat: P37089

Synonyms:Amiloride-sensitive sodium channel subunit alpha ;Alpha-NaCH;Epithelial Na;+ channel subunit alpha;Alpha-ENaC;ENaCA;Nonvoltage-gated sodium channel 1 subunit alpha;SCNEA

GeneID:Human: 6337