RPTOR Antibody, HRP conjugated - Cat. #: CSB-PA839774LB01HU

SKU: CSB-PA839774LB01HU

Size :50ug

Clone Number:

Aliases:KIAA1303 antibody; KOG1 antibody; Mip1 antibody; P150 target of rapamycin (TOR) scaffold protein antibody; p150 target of rapamycin (TOR) scaffold protein containing WD repeats antibody; P150 target of rapamycin (TOR)-scaffold protein antibody; Raptor antibody; Regulatory associated protein of mTOR antibody; Regulatory associated protein of MTOR complex 1 antibody; Regulatory-associated protein of mTOR antibody; RPTOR antibody; RPTOR_HUMAN antibody

Product Type:Polyclonal Antibody

Immunogen Species:Homo sapiens (Human)

UniProt ID:Q8N122

Immunogen:Recombinant Human Regulatory-associated protein of mTOR protein (13-128AA)

Raised in:Rabbit

Species Reactivity:Human

Tested Applications:ELISA

Background:Involved in the control of the mammalian target of rapamycin complex 1 (mTORC1) activity which regulates cell growth and survival, and autophagy in response to nutrient and hormonal signals; functions as a scaffold for recruiting mTORC1 substrates. mTORC1 is activated in response to growth factors or amino acids. Growth factor-stimulated mTORC1 activation involves a AKT1-mediated phosphorylation of TSC1-TSC2, which leads to the activation of the RHEB GTPase that potently activates the protein kinase activity of mTORC1. Amino acid-signaling to mTORC1 requires its relocalization to the lysosomes mediated by the Ragulator complex and the Rag GTPases. Activated mTORC1 up-regulates protein synthesis by phosphorylating key regulators of mRNA translation and ribosome synthesis. mTORC1 phosphorylates EIF4EBP1 and releases it from inhibiting the elongation initiation factor 4E (eiF4E). mTORC1 phosphorylates and activates S6K1 at \\\'Thr-389\\\', which then promotes protein synthesis by phosphorylating PDCD4 and targeting it for degradation. Involved in ciliogenesis.

Clonality:Polyclonal

Isotype:IgG

Purification Method:>95%, Protein G purified

Conjugate:HRP

Buffer:Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form:Liquid

Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names:RPTOR

Research Areas:Epigenetics and Nuclear Signaling; Cell biology; Signal transduction