RFX6 Antibody, HRP conjugated - Cat. #: CSB-PA812809LB01HU

SKU: CSB-PA812809LB01HU

Size :50ug

Clone Number:

Aliases:RFX6 antibody; RFXDC1 antibody; DNA-binding protein RFX6 antibody; Regulatory factor X 6 antibody; Regulatory factor X domain-containing protein 1 antibody

Product Type:Polyclonal Antibody

Immunogen Species:Homo sapiens (Human)

UniProt ID:Q8HWS3

Immunogen:Recombinant Human DNA-binding protein RFX6 protein (1-260AA)

Raised in:Rabbit

Species Reactivity:Human

Tested Applications:ELISA

Background:Transcription factor required to direct islet cell differentiation during endocrine pancreas development. Specifically required for the differentiation of 4 of the 5 islet cell types and for the production of insulin (PubMed:20148032, PubMed:25497100). Not required for pancreatic PP (polypeptide-producing) cells differentiation. Acts downstream of NEUROG3 and regulates the transcription factors involved in beta-cell maturation and function, thereby restricting the expression of the beta-cell differentiation and specification genes, and thus the beta-cell fate choice. Activates transcription by forming a heterodimer with RFX3 and binding to the X-box in the promoter of target genes (PubMed:20148032). Involved in glucose-stimulated insulin secretion by promoting insulin and L-type calcium channel gene transcription (PubMed:25497100).

Clonality:Polyclonal

Isotype:IgG

Purification Method:>95%, Protein G purified

Conjugate:HRP

Buffer:Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form:Liquid

Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names:RFX6

Research Areas:Others