RFFL Antibody - Cat. #: CSB-PA848846DSR1HU

SKU: CSB-PA848846DSR1HU

Size :50ul

Clone Number:

Aliases:CARP-2 antibody; CARP2 antibody; Caspase regulator CARP2 antibody; Caspases 8 and 10 associated RING finger protein 2 antibody; caspases-8 and -10- associated RING finger protein 2 antibody; Caspases-8 and -10-associated RING finger protein 2 antibody; E3 ubiquitin protein ligase rififylin antibody; E3 ubiquitin-protein ligase rififylin antibody; Fring antibody; FYVE RING finger protein Sakura antibody; FYVE-RING finger protein Sakura antibody; Rffl antibody; RFFL_HUMAN antibody; Rififylin antibody; RING finger and FYVE like domain containing protein antibody; RING finger and FYVE-like domain-containing protein 1 antibody; RING finger protein 189 antibody; RING finger protein 34 like antibody; RING finger protein 34-like antibody; RNF189 antibody; RNF34L antibody

Product Type:Polyclonal Antibody

Immunogen Species:Homo sapiens (Human)

UniProt ID:Q8WZ73

Immunogen:Recombinant Human E3 ubiquitin-protein ligase rififylin protein (1-190AA)

Raised in:Rabbit

Species Reactivity:Human

Tested Applications:ELISA, IHC; Recommended dilution: IHC:1:20-1:200

Background:E3 ubiquitin-protein ligase that regulates several biological processes through the ubiquitin-mediated proteasomal degradation of various target proteins. Mediates \\\'Lys-48\\\'-linked polyubiquitination of PRR5L and its subsequent proteasomal degradation thereby indirectly regulating cell migration through the mTORC2 complex. Ubiquitinates the caspases CASP8 and CASP10, promoting their proteasomal degradation, to negatively regulate cell death downstream of death domain receptors in the extrinsic pathway of apoptosis. Negatively regulates the tumor necrosis factor-mediated signaling pathway through targeting of RIPK1 to ubiquitin-mediated proteasomal degradation. Negatively regulates p53/TP53 through its direct ubiquitination and targeting to proteasomal degradation. Indirectly, may also negatively regulate p53/TP53 through ubiquitination and degradation of SFN. May also play a role in endocytic recycling.

Clonality:Polyclonal

Isotype:IgG

Purification Method:Antigen Affinity Purified

Conjugate:Non-conjugated

Buffer:PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Form:Liquid

Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names:RFFL

Research Areas:Epigenetics and Nuclear Signaling; Cell biology; Signal transduction