RFA1 rabbit pAb

SKU: ES20438

Size: 100μL

Source:Rabbit

Applications:WB;ELISA;IHC

Reactivity:Human;Monkey;Mouse;Rat

Dilution:WB 1:500-2000;IHC-p 1:50-300; ELISA 2000-20000

Immunogen:Synthesized peptide derived from human RFA1

Storage_stability:-20°C/1 year

Clonality:Polyclonal

Isotype:IgG

Concentration:1 mg/ml

Observed_band(KD):

Human_gene_id:6117

Human_swiss_prot_no:P27694

Subcellular_location:Nucleus . Nucleus, PML body . Enriched in PML bodies in cells displaying alternative lengthening of their telomeres. .

Other_name:Replication protein A 70 kDa DNA-binding subunit (RP-A p70;Replication factor A protein 1;RF-A protein 1;Single-stranded DNA-binding protein)

Background:function:It participates in a very early step in initiation. RP-A is a single-stranded DNA-binding protein. Absolutely required for simian virus 40 DNA replication in vitro.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Belongs to the replication factor A protein 1 family.,subunit:Heterotrimer of 70, 32 and 14 kDa chains. The DNA-binding activity may reside exclusively on the 70 kDa subunit. Interacts with RIP and XPA. Interacts with RPA4.,