Recombinant VE-Cadherin/CD144 Monoclonal Antibody

SKU: AN300185P

Size::20μL

Storage:This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles.

Shipping:Ice bag

Exp date:12 months

Category ID_II:Primary Antibodies

Category ID_III:Recombinant Antibodies

Abbreviation:CDH5

Target Synonym:CDH;Cadherin 5 Type;cadherin;CDH5;7B4;CD144;cadherin-5;Cadherin 5 Type 2;VE-Cadherin;Cadherin-5;7B 4;7B4 antigen;CADH5;Cadherin 5;Cadherin5;CD 144;CD144 antigen;CDH 5;CDH5 protein;Endothelial specific cadherin;FLJ17376;OTTHUMP00000174777;type 2;type 2 (vascular endothelium);vascular endothelial;Vascular endothelial cadherin;Vascular epithelium cadherin;VE Cad;VE cadherin (vascular epithelium);VEC

Research Areas:Signal Transduction;Cancer;Cardiovascular;Tags & Cell Markers

Conjugation:Unconjugated

Host:Rabbit

Species reactivity:Human

Application:IHC-P

Isotype:IgG

Clonality:Rabbit Monoclonal

Clone NO.:5C2

UNIProt ID:P33151

Accession:

Background:Cadherins (Calcium dependent adhesion molecules) are a class of transmembrane proteins. Cadherin-5, also known as VE-cadherin, CDH5 and CD144, an endothelial specific cell-cell adhesion molecule, plays a pivotal role in the formation, maturation and remodeling of the vascular wall. VE-Cadherin is widely considered to be specific for vascular endothelia in which it is either the sole or the predominant cadherin, often co-existing with N-cadherin. This specificity of VE-cadherin for vascular endothelial cells is important not only in blood and lymph vessel biology and medicine, but also for cell-type-based diagnoses, notably those of metastatic tumors. As a classical cadherin, VE-Cadherin links endothelial cells together by homophilic interactions mediated by its extracellular part and associates intracellularly with the actin cytoskeleton via catenins. Mechanisms that regulate VE-cadherin-mediated adhesion are important for the control of vascular permeability and leukocyte extravasation. In addition to its adhesive functions, VE-Cadherin regulates various cellular processes such as cell proliferation and apoptosis and modulates vascular endothelial growth factor receptor functions. Consequently, VE-cadherin is essential during embryonic angiogenesis.

Concentration:1 mg/mL

Immunogen:Recombinant Human VE-Cadherin / CD144 Protein

Buffer:0.2 μm filtered solution in PBS

Purification method:Protein A

Dilution:IHC-P 1:250-1:1000;

Calculated MW:

ObservedMW: