Recombinant TDP43 Monoclonal Antibody

SKU: AN300963L

Size::50μL

Storage:Store at -20℃ Valid for 12 months. Avoid freeze / thaw cycles.

Shipping:Ice bag

Exp date:12 months

Category ID_II:Primary Antibodies

Category ID_III:Recombinant Antibodies;Monoclonal Antibodies

Abbreviation:TDP43

Target Synonym:ALS;TDP;ALS10;TDP-43;TARDBP;TDP43;along with a truncated 20-28 kDa form;and 99% aa identity with rat TDP-43.;human and mouse TDP-43 share 100% aa sequence identity;in ubiquitin-containing inclusion bodies. TDP-43 can also influence CFTR exon 9 skipping in cystic fibrosis. Within aa 1-103;TDP-43 (TAR DNA binding protein of 43 kDa;TADBP

Research Areas:Microbiology;Neuroscience;Epigenetics and Nuclear Signaling

Conjugation:Unconjugated

Host:Rabbit

Species reactivity:Human;Mouse;Rat

Application:WB

Isotype:IgG,κ

Clonality:Monoclonal;Recombinant

Clone NO.:6F5

UNIProt ID:Q13148

Accession:

Background:TAR DNA binding protein(TARDBP) Homo sapiens HIV-1, the causative agent of acquired immunodeficiency syndrome (AIDS), contains an RNA genome that produces a chromosomally integrated DNA during the replicative cycle. Activation of HIV-1 gene expression by the transactivator Tat is dependent on an RNA regulatory element (TAR) located downstream of the transcription initiation site. The protein encoded by this gene is a transcriptional repressor that binds to chromosomally integrated TAR DNA and represses HIV-1 transcription. In addition, this protein regulates alternate splicing of the CFTR gene. A similar pseudogene is present on chromosome 20.

Concentration:0.2 mg/mL

Immunogen:Recombinant Human TDP43 protein

Buffer:PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.

Purification method:Protein A

Dilution:WB 1:1000-1:5000

Calculated MW:45 kDa

ObservedMW:45 kDa