Recombinant Rhesus macaque IFNAR1 Protein (His Tag)

SKU: PKSQ050073

Size: 50μg

Storage: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.

Shipping: This product is provided as lyophilized powder which is shipped with ice packs.

Exp date: 12 months

Category ID_II: Recombinant Proteins

Category ID_III: Others

Abbreviation: IFNAR1

Target Synonym: AVP;Alpha-type antiviral protein;CRF2-1;Cytokine receptor class-II member 1;Cytokine receptor family 2 member 1;I;IFN-alpha-REC;IFN-alpha/beta R1;IFN-alpha/beta receptor 1;beta-type antiviral protein;human interferon-alpha receptor (HuIFN-alpha-Rec)10IFRC

Research Areas:

Conjugation:

Target Species: Rhesus macaque

Expression Host: HEK293 Cells

Application:

Fusion tag: C-His

UNIProt ID: A0A7N9D7J0

Accession: XP_005548864.1

Background: Interferon-alpha/beta receptor 1 (IFN-alpha / beta R1), also known as IFNAR1, are present in all tissues and even on the surface of most IFN-resistant cells. Isoform 1, isoform 2 and isoform 3 are expressed in the IFN-alpha sensitive myeloma cell line U266B1. Isoform 2 and isoform 3 are expressed in the IFN-alpha resistant myeloma cell line U266R. Isoform 1 is not expressed in IFN-alpha resistant myeloma cell line U266R. It interacts with STAT1 and STAT2, the interaction requires its phosphorylation at Tyr-466. It also interacts with FBXW11, the substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex.

Concentration:

Activity: Not validated for activity

Sequence: Ala25-Lys437

Purity: > 95 % as determined by reducing SDS-PAGE.

Formulation: Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.
Normally 5% - 8% trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization.
Please refer to the specific buffer information in the printed manual.

Reconstitution: Please refer to the printed manual for detailed information.

Endotoxin: < 1.0 EU per μg of the protein as determined by the LAL method.

Calculated MW: 48.4 kDa

ObservedMW: 70-120 kDa