Recombinant Rat NAP-2/CXCL7 protein

SKU: CD00085

Size:2 ug

Background:CXCL7 is a small cytokine which is also an isoform of Beta-Thromboglobulin or Pro-Platelet basic protein belonging to the CXC chemokine family and it is released in large amounts from platelets following their activation. CXCL7 stimulates DNA synthesis, mitosis, glycolysis, intracellular cAMP accumulation, prostaglandin E2 secretion, and synthesis of hyaluronic acid and sulfated glycosaminoglycan. It also stimulates the formation and secretion of plasminogen activator by human synovial cells. Recombinant Rat CXCL7 contains 62 amino acids which is a single non-glycosylated polypeptide chain. In addition, The rat CXCL7 shares 58 % and 77 % a.a. sequence identity with human and mouse CXCL7.

Research_area:Immunology

Purity:> 97 % by SDS-PAGE and HPLC analyses.

Source:Escherichia coli.

Full product name:Recombinant Rat Neutrophil Activating Peptide 2/CXCL7

Biological activity:Fully biologically active when compared to standard. The biologically active determined by a chemotaxis bioassay using human CXCR2 transfected Mouse BaF3 cells is in a concentration range of .1-1. ng/ml.

Synonyms:NAP-2/CXCL7,Cxcl7; Nap-2,Ppbp, Rat

Endotoxin:Less than 1 EU/μg of rRtNAP-2/CXCL7 as determined by LAL method.

Storage:-20ºC

Sequence:IELRCRCTNT LSGIPLNSIS RVNVFRPGAH CDNVEVIATL KNGKEVCLDP TAPMIKKIVK KI

uniprot accession:Q99ME

Molecular weight:Approximately 6.8 kDa, a single non-glycosylated polypeptide chain containing 62 amino acids.

Formulation:

Reconstitution:Lyophilized from a .2 μm filtered concentrated solution in PBS, pH 7.4.