Recombinant Rat Gremlin-1(Grem1)

Recombinant Rat Gremlin-1(Grem1)

CSB-EP009892RAc7
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Size: 200ug. Other sizes are also available. Please Inquire.

In Stock: No

Lead time: 10-20 working days

Research Topic: Cardiovascular

Uniprot ID: O35793

Gene Names: Grem1

Organism: Rattus norvegicus (Rat)

AA Sequence: KKKGSQGAIPPPDKAQHNDSEQTQSPPQPGSRTRGRGQGRGTAMPGEEVLESSQEALHVTERKYLKRDWCKTQPLKQTIHEEGCNSRTIINRFCYGQCNSFYIPRHIRKEEGSFQSCSFCKPKKFTTMMVTLNCPELQPPTKKKRVTRVKQCRCISIDLD

Expression Region: 25-184aa

Sequence Info: Full Length of Mature Protein

Source: E.coli

Tag Info: C-terminal 6xHis-tagged

MW: 20.2 kDa

Alternative Name(s): Cysteine knot superfamily 1, BMP antagonist 1 Down-regulated in Mos-transformed cells protein Cktsf1b1, Drm

Relevance: Cytokine that may play an important role during carcinogenesis and metanephric kidney organogenesis, as a BMP antagonist required for early limb outgrowth and patterning in maintaining the FGF4-SHH feedback loop. Down-regulates the BMP4 signaling in a dose-dependent manner. Antagonist of BMP2; inhibits BMP2-mediated differentiation of osteoblasts (in vitro).Acts as inhibitor of monocyte chemotaxis. Can inhibit the growth or viability of normal cells but not transformed cells when is overexpressed.

Reference: "Identification of drm, a novel gene whose expression is suppressed in transformed cells and which can inhibit growth of normal but not transformed cells in culture." Topol L.Z., Marx M., Laugier D., Bogdanova N.N., Boubnov N.V., Clausen P.A., Calothy G., Blair D.G. Mol. Cell. Biol. 17:4801-4810(1997)

Purity: Greater than 85% as determined by SDS-PAGE.

Storage Buffer: Tris-based buffer,50% glycerol

Storage: The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20℃/-80℃. The shelf life of lyophilized form is 12 months at -20℃/-80℃.

Notes: Repeated freezing and thawing is not recommended. Store working aliquots at 4℃ for up to one week.