Recombinant PTPN12 Monoclonal Antibody

SKU: AN301790L

Size::50μL

Storage:Store at -20℃ Valid for 12 months. Avoid freeze / thaw cycles.

Shipping:Ice bag

Exp date:12 months

Category ID_II:Primary Antibodies

Category ID_III:Monoclonal Antibodies;Recombinant Antibodies

Abbreviation:PTPN12

Target Synonym:PTPG;PTPN;PTPG1;PTP-PEST;PTPN12;PTP-PEST;Protein tyrosine phosphatase G1;Protein tyrosine phosphatase non receptor type 12;Protein-tyrosine phosphatase G1;PTN12;PTP PEST;Tyrosine protein phosphatase non receptor type 12;Tyrosine-protein phosphatase non-receptor type 12

Research Areas:Signal Transduction

Conjugation:Unconjugated

Host:Rabbit

Species reactivity:Human;Rat;Mouse

Application:WB

Isotype:IgG,κ

Clonality:Monoclonal;Recombinant

Clone NO.:A502

UNIProt ID:Q05209

Accession:

Background:PTPN12 is a member of the protein tyrosine phosphatase (PTP) family. PTPs are signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains a C-terminal PEST motif, which serves as a protein-protein interaction domain, and may regulate protein intracellular half-life. This PTP was found to bind and dephosphorylate the product of the oncogene c-ABL and thus may play a role in oncogenesis. This PTP was also shown to interact with, and dephosphorylate, various products related to cytoskeletal structure and cell adhesion, such as p130 (Cas), CAKbeta/PTK2B, PSTPIP1, and paxillin. This suggests it has a regulatory role in controlling cell shape and mobility.

Concentration:1 mg/mL

Immunogen:Recombinant human PTPN12 fragment

Buffer:PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.

Purification method:Protein A purified

Dilution:WB 1:1000-1:5000

Calculated MW:88 kDa

ObservedMW:120 kDa