Recombinant Phospho-IGF1R (Tyr1131)/Insulin Receptor β (Tyr1146) Monoclonal Antibody

SKU: AN300051L

Size::20μL

Storage:This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles.

Shipping:Ice bag

Exp date:12 months

Category ID_II:Primary Antibodies

Category ID_III:Recombinant Antibodies

Abbreviation:IGF1R

Target Synonym:JTK;IGF1R;CD221;IGFIR;IGFR;JTK13;CD221 antigen;IGF-1R;IGF-I R;IGF-I receptor;IGF-IR;insulin-like growth factor 1 receptor

Research Areas:Signal Transduction;Cancer;Developmental Biology;Neuroscience;Cardiovascular;Metabolism

Conjugation:Unconjugated

Host:Rabbit

Species reactivity:Human

Application:WB

Isotype:IgG

Clonality:Rabbit Monoclonal

Clone NO.:2C7

UNIProt ID:P08069

Accession:

Background:This receptor binds insulin-like growth factor with a high affinity. It has tyrosine kinase activity. The insulin-like growth factor I receptor plays a critical role in transformation events. Cleavage of the precursor generates alpha and beta subunits. It is highly overexpressed in most malignant tissues where it functions as an anti-apoptotic agent by enhancing cell survival. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.

Concentration:1 mg/mL

Immunogen:A synthetic phosphopeptide corresponding to residues around Tyr1131 of the Human Phospho-IGF1R or Tyr1146 of the Human Insulin Receptor β

Buffer:10 mM sodium HEPES, 150 mM NaCl, 100 μg/mL protein protectant, 50% glycerol, pH 7.5

Purification method:Protein A

Dilution:WB 1:1000-1:10000;

Calculated MW:154 kDa

ObservedMW:100 kDa