Recombinant Phospho-Chk1 (Ser317) Monoclonal Antibody

SKU: AN300380L

Size::20μL

Storage:This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles.

Shipping:Ice bag

Exp date:12 months

Category ID_II:Primary Antibodies

Category ID_III:Acetyl/Phospho/Methyl Antibodies;Recombinant Antibodies;Monoclonal Antibodies

Abbreviation:CHEK1

Target Synonym:CHK;CHEK;CHEK1;CHK1

Research Areas:Epigenetics and Nuclear Signaling;Cancer

Conjugation:Unconjugated

Host:Rabbit

Species reactivity:Human

Application:WB;IHC-P

Isotype:IgG

Clonality:Monoclonal

Clone NO.:11G3

UNIProt ID:O14757

Accession:

Background:The protein encoded by this gene belongs to the Ser/Thr protein kinase family. It is required for checkpoint mediated cell cycle arrest in response to DNA damage or the presence of unreplicated DNA. This protein acts to integrate signals from ATM and ATR, two cell cycle proteins involved in DNA damage responses, that also associate with chromatin in meiotic prophase I. Phosphorylation of CDC25A protein phosphatase by this protein is required for cells to delay cell cycle progression in response to double-strand DNA breaks. Several alternatively spliced transcript variants have been found for this gene.

Concentration:1 mg/mL

Immunogen:A synthetic phosphopeptide corresponding to residues around Ser317 of human Chk1.

Buffer:10 mM sodium HEPES, 150 mM NaCl, 100 μg/mL protein protectant, 50% glycerol, pH 7.5

Purification method:Protein A

Dilution:WB 1:1000-1:2000;IHC-P 1:500-1:2000

Calculated MW:54 kDa

ObservedMW:58 kDa