Recombinant p21 Monoclonal Antibody

SKU: AN301027L

Size::50μL

Storage:Store at -20℃ Valid for 12 months. Avoid freeze / thaw cycles.

Shipping:Ice bag

Exp date:12 months

Category ID_II:Primary Antibodies

Category ID_III:Recombinant Antibodies;Monoclonal Antibodies

Abbreviation:P21

Target Synonym:WAF;SDI;CIP;CAP;PIC;CDKN;CDK-interacting protein;cyclin-dependent kinase inhibitor;Melanoma differentiation-associated protein;p21CIP;Slc12a;MDA;CDKN1A;CAP20;CDKN1;CIP1;MDA-6;P21;SDI1;WAF1;p21CIP1;cyclin-dependent kinase inhibitor 1;CDKI;CDK-interacting protein 1;CDN1A;Cyclin Dependent Kinase Inhibitor 1A;DNA Synthesis Inhibitor;Melanoma differentiation-associated protein 6;P21waf;SLC12A9;FASN;FAS;MDA6;PIC1;CAP20;CDKN1;CIP1;cyclin-dependent kinase inhibitor 1;MDA-6;P21;p21CIP1;SDI1;WAF1;cyclin-dependent kinase inhibitor 1A

Research Areas:Cell Biology;Epigenetics and Nuclear Signaling;Cancer;Kits;Lysates;Other

Conjugation:Unconjugated

Host:Rabbit

Species reactivity:Human;Rat

Application:WB;IHC

Isotype:IgG,κ

Clonality:Monoclonal;Recombinant

Clone NO.:5A2

UNIProt ID:P38936

Accession:

Background:This gene encodes a potent cyclin-dependent kinase inhibitor. The encoded protein binds to and inhibits the activity of cyclin-cyclin-dependent kinase2 or -cyclin-dependent kinase4 complexes, and thus functions as a regulator of cell cycle progression at G1. The expression of this gene is tightly controlled by the tumor suppressor protein p53, through which this protein mediates the p53-dependent cell cycle G1 phase arrest in response to a variety of stress stimuli. This protein can interact with proliferating cell nuclear antigen, a DNA polymerase accessory factor, and plays a regulatory role in S phase DNA replication and DNA damage repair. This protein was reported to be specifically cleaved by CASP3-like caspases, which thus leads to a dramatic activation of cyclin-dependent kinase2, and may be instrumental in the execution of apoptosis following caspase activation. Mice that lack this gene have the ability to regenerate damaged or missing tissue. Multiple alternatively spliced variants have been found for this gene.

Concentration:0.2 mg/mL

Immunogen:Recombinant Human p21 protein

Buffer:PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.

Purification method:Protein A

Dilution:IHC 1:100-1:200;WB 1:1000-1:5000

Calculated MW:18 kDa

ObservedMW:18 kDa