Recombinant Mouse NRG-1 Protein(His Tag)

SKU: PDMM100120

Size:100μg

Storage:Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.

Shipping:This product is provided as lyophilized powder which is shipped with ice packs.

Exp date:12 months

Category ID_II:Recombinant Proteins

Category ID_III:Others

Abbreviation:NRG-1

Target Synonym:Acetylcholine receptor-inducing activity;Acetylcholine receptor-inducing activity; CHICK; homolog of;ARIA;Breast cancer cell differentiation factor p45;GGF;GGF2;Glial growth factor;Heregulin;heregulin; alpha (45kD; ERBB2 p185-activator);HGL;HRG;HRG1;HRGA;MST131;NDF;Neu differentiation factor;Neuregulin 1;neuregulin 1 type IV beta 1a;neuregulin 1 type IV beta 3;Neuregulin-1;NRG 1;nrg1;NRG1-IT2;NRG1_HUMAN

Research Areas:

Conjugation:

Target Species:Mouse

Expression Host:Mammalian

Application:

Fusion tag:C-His

UNIProt ID:Q6DR98

Accession:Q6DR98

Background:Neuregulin 1 or NRG1 is one of four proteins in the neuregulin family that act on the EGFR family of receptors. This growth factor was originally identified as a 44-kD glycoprotein that interacts with the NEU / ERBB2 receptor tyrosine kinase to increase its phosphorylation on tyrosine residues. NRG1 is a trophic factor that has been implicated in neural development, neurotransmission, and synaptic plasticity. NRG1 has multiple isoforms that are generated by the usage of different promoters and alternative splicing of a single gene. Neuregulin 1 (NRG1) is essential for the development and function of multiple organ systems, and its dysregulation has been linked to diseases such as cancer and schizophrenia. NRG1 is a schizophrenia candidate gene and plays an important role in brain development and neural function. Schizophrenia is a complex disorder, with etiology likely due to epistasis.

Concentration:

Activity:Not validated for activity

Sequence:Ser177-Gln237

Purity: > 90% as determined by reducing SDS-PAGE.

Formulation:Lyophilized from a 0.2 μm filtered solution in PBS with 5% Trehalose and 5% Mannitol.

Reconstitution:It is recommended that sterile water be added to the vial to prepare a stock solution of 0.5 mg/mL. Concentration is measured by UV-Vis.

Endotoxin:< 1.0 EU/mg of the protein as determined by the LAL method.

Calculated MW:6.6 kDa

ObservedMW:50 kDa