Recombinant Mouse IL-11 protein

SKU: CD00392

Size:2 ug

Background:Interleukin-11 (IL-11) is encoded by the IL11 gene. IL-11 is a multifunctional cytokine first isolated from bone marrow-derived stromal cells. IL-11 receptor activation requires formation of a complex of two IL-11 molecules with two molecules of the ligand-binding IL-11 Rα subunit and two molecules of the expressed cell signaling β subunit, gp130. IL-11 is a member of the IL-6 superfamily, distinguished based on their use of the common co-receptor gp130. IL-11 can directly stimulate the proliferation of hematopoietic stem cells and megakaryocyte progenitor cells, and induce megakaryocyte maturation resulting in increased platelet production. Mature Mouse IL-11 shares 88 % amino acid sequence identity with human IL-11.

Research_area:Immunology

Purity:> 97 % by SDS-PAGE and HPLC analyses.

Source:Escherichia coli.

Full product name:Recombinant Mouse Interleukin-11

Biological activity:Fully biologically active when compared to standard. The ED5 as determined by a cell proliferation assay using Mouse T11 cells is less than 2 ng/ml, corresponding to a specific activity of > 5. × 15 IU/mg.

Synonyms:IL-11,IL-, IL11, Mouse

Endotoxin:Less than 1 EU/μg of rMuIL-11 as determined by LAL method.

Storage:-20ºC

Sequence:MPGPPAGSPR VSSDPRADLD SAVLLTRSLL ADTRQLAAQM RDKFPADGDHSLDSLPTLAM SAGTLGSLQL PGVLTRLRVD LMSYLRHVQW LRRAGGPSLKTLEPELGALQ ARLERLLRRL QLLMSRLALP QAAPDQPVIP LGPPASAWGSIRAAHAILGG LHLTLDWAVR GLLLLKTRL

uniprot accession:P47873

Molecular weight:Approximately 19.1 kDa, a single non-glycosylated polypeptide chain containing 179 amino acids.

Formulation:

Reconstitution:Lyophilized from a .2 μm filtered solution in PBS, pH 7.4.