Recombinant Mouse Exodus-2/CCL21 protein

SKU: CD00469

Size:5 ug

Background:CCL21 is encoded by CCL21 gene that is located in Chr. 4 and shows 21-33 % identity to other CC chemokines. This chemokine contains the four conserved cysteines characteristic of β chemokines plus two additional cysteines in its unusually long carboxylterminal domain. Human and mouse CCL21 are highly conserved, exhibiting 86 % amino acid sequence identity. CCL21 is highly expressed in lymph nodes of certain endothelial cells, and in the spleen and appendix. It elicits effects by binding with CCR7, having functions of T and B lymphocytes chemotaxis and inhibiting hematopoiesis.

Research_area:Immunology

Purity:> 97 % by SDS-PAGE and HPLC analyses.

Source:Escherichia coli.

Full product name:Recombinant Mouse Exodus-2/CCL21

Biological activity:Fully biologically active when compared to standard. The biological activity determined by a chemotaxis bioassay using Mouse T-lymphocytes is in a concentration range of 1-1 ng/ml.

Synonyms:Exodus-2/CCL21,6CKBAC, 6CKBAC2, 6Cki, 6Ckine, ALP, AW987545, CKb9, Exodus, Gm1987, SCYA21a, SLC, Scya, Scya2, Scya21, Scya21b, Tca, Tca4, plt, Mouse

Endotoxin:Less than 1 EU/μg of rMuExodus-2/CCL21 as determined by LAL method.

Storage:-20ºC

Sequence:SDGGGQDCCL KYSQKKIPYS IVRGYRKQEP SLGCPIPAIL FLPRKHSKPE LCANPEEGWV QNLMRRLDQP PAPGKQSPGC RKNRGTSKSG KKGKGSKGCK RTEQTQPSRG

uniprot accession:P86792;P86793;P84444

Molecular weight:Approximately 12.1 kDa, a single, non-glycosylated polypeptide chain containing 11 amino acids.

Formulation:

Reconstitution:Lyophilized from a .2 μm filtered concentrated solution in 2 mM PB, pH 7.4, 15 mM NaCl.