Recombinant Macaca nemestrina PCSK9/Proprotein Convertase 9 Protein (His Tag)

SKU: PKSQ050064

Size: 50μg

Storage: Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.

Shipping: This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C.

Exp date: 12 months

Category ID_II: Recombinant Proteins

Category ID_III: Others

Abbreviation: PCSK9;Proprotein Convertase 9

Target Synonym: PC9;PCSK9;Proprotein Convertase 9;Proprotein Convertase Subtilisin/Kexin Type 9;Subtilisin/Kexin-Like Protease PC9

Research Areas:

Conjugation:

Target Species: Macaca nemestrina

Expression Host: HEK293 Cells

Application:

Fusion tag: C-His

UNIProt ID: A8T662

Accession: A8T662

Background: Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) is a secretory subtilase belonging to the proteinase K subfamily. PCSK9 is synthesized as a soluble zymogen that undergoes autocatalytic intramolecular processing in the ER , the pro domain and mature chain secrete together through noncovalent interactions. PCSK9 binds with low-density lipoprotein receptor (LDLR) and plays a major regulatory role in cholesterol homeostasis. PCSK9 also plays a role in the neural development.

Concentration:

Activity: Not validated for activity

Sequence: Gln31-Gln152&Ser153-Gln692

Purity: > 95 % as determined by reducing SDS-PAGE.

Formulation: Supplied as a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, 0.1M Arg, 0.1M Glu, 20% glycerol, 0.01% tween20, 5% Trehalose, pH 6.0.

Reconstitution: Not Applicable

Endotoxin: < 1.0 EU per μg of the protein as determined by the LAL method.

Calculated MW: 14&59 kDa

ObservedMW: 16-21&55-77 kDa